Effects of Dextran Sodium Sulfate MP on Colon HA Deposition

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When the intestine is inflamed, hyaluronan (HA) deposition is often increased. This HA deposition may promote intestinal inflammation, and it is possible that the increased HA deposition during colitis induction was accompanied by changes in colon HA deposition. Therefore, we performed an experiment to study the effect of Dextran sodium sulfate (DSS) on colon HA deposition.

To establish the effects of DSS on colon HA deposition, we used an experimental model of colitis in mice. We administered mice with 80 mg/kg body weight/d of GAGs for one day prior to the experimental period, and again during the experimental period. After a period of four days, we offered the mice drinking water with 1.5% sodium sulfate for five days. During this time, we measured changes in the wet mass of each hydrogel, and examined the inflammatory infiltrate in the intestine. In addition, we investigated the effect of FCS on expression of critical genes involved in inflammatory processes, including TNFa, COX-2, and iNOS. The results showed that FCS attenuated colitis caused by DSS in the mouse model. Additionally, we found that FCS also attenuated inflammation in a mouse model of ear inflammation.

In addition, FCS also inhibited the inflammatory response to TPA. Therefore, we also evaluated the effect of sea cucumber GAGs on the colitis-induced colitis in mice. Sea cucumbers are native to the Yucatan Peninsula and have strong anti-inflammatory properties in vivo. Furthermore, these anti-inflammatory effects are mainly mediated by fucosylated chondroitin sulfate, which is the principal component of the body wall.

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