Calcium carbonate nanoparticles (CaCO3NPs) are an excellent drug delivery system. They are also used in biomedical applications such as bone engineering and tissue injury repair. CaCO3NPs have several advantages over other calcium-containing compounds, including low toxicity and high pH-sensitivity. They are widely used in the manufacture of various plastics, paints, and paper products.
Synthesis of caco3 nanoparticles via a biosynthesis route: a green approach
The biosynthesis route enables the production of CCNPs in a sustainable manner without using harmful chemicals and harsh physical conditions. In this method, naturally occurring plant extracts and biomolecules are employed in the synthesis of the nanoparticles. The resulting caco3 nanoparticles can be used as an encapsulant for biomolecules, such as enzymes and hydrophilic drugs.
Stable vaterite nanoparticles: a platform for encapsulation and biosensors
The stability of vaterite nanoparticles was evaluated after storage in aqueous buffer for more than 5 months. These particles retain their crystalline structure, surface charge, and their agglomeration properties, making them an excellent encapsulating platform for a large variety of biomolecules.
Curcumin-loaded cockle shell-derived calcium carbonate nanoparticles: a promising strategy to ameliorate lead-induced neurotoxicity
In this study, the effect of curcumin loaded cockle shell-derived CaCO3NPs (Cur-CSCaCO3NP) on lead-induced neurotoxicity was studied in rats. The CaCO3NPs exhibited anti-oxidative and anti-inflammatory activities. Moreover, these nanoparticles showed higher cellular uptake and nuclear localization compared with unmodified CaCO3NPs.
Toxicological studies: cell and zebrafish modeling
In this study, the cytotoxic effects of different concentrations of CaCO3NPs on two mouse embryonic fibroblast (NIH 3T3) and human breast adenocarcinoma cell lines were examined in vitro and in vivo. The results indicated that the toxicity of CaCO3NPs mainly depended on the cell viability as an indicator of their sensitivity to the toxicological effects of nanoparticles.