Photothermal therapy of Fe3O4 magnetic nanoparticles and their custom synthesized composite materials

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Fe3O4 The nanoparticles used in biomedicine are characterized by their high magnetic saturation and biocompatibility. Recently, Fe3O4 Nanoparticles attracted researchers’ attention as a type of new photothermal reagent.Fe3O4 (microspheres) clusters, compared to Fe3O4 with the same crystallization, have a superior photothermal effect. This is due in part to their stronger absorption functions within the near-infrared spectrum. Fe3O4 Microspheres also showed a greater photothermal treatment under near-infrared lights.
The photothermal properties can be further explored by utilizing Fe3O4 Researchers have found that with increasing storage time, Fe3O4 is partially oxidized to Fe2O3. They also discovered that polymer ligands are more protective than small molecule ligands. Fe3O4 becomes partially oxidized with the increase in storage time. Research has shown that polymer molecules have a greater protective effect than small molecule molecules, and also have the ability to resist oxidation.

By oxidatively self-polymerizing dopamine (PDA), a composite core-shell microsphere structure with high biocompatibility is created by using Fe3O4 nanospheres as the core. The composite microspheres exhibit greater photothermal effects and absorption near infrared compared to Fe3O4 microspheres. The photothermal and near-infrared effects of Fe3O4&PDA Composite Microspheres are both enhanced with increasing thickness of PDA shell.
The nanoparticles will enter the blood and combine with different proteins, creating a protein crown. This is then absorbed and eliminated by autoimmune system and mononuclear lymphocytes. Biomimetic technology was used to create the Fe3O4 The microspheres have been coated with membranes of red blood cells (RBCs), which greatly improves their long-circulation capability in the body. They are then able to enhance the composite microspheres on the tumor site and significantly increase the photothermal effect.
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